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Home>Morag's desk>Tamoxifen – breast cancer and scar use?

Tamoxifen – breast cancer and scar use?

Tamoxifen, a non-steroidal anti-estrogen, which is commonly used in breast cancer may lead to improved wound healing in keloids by decreasing the expression of TGF-beta(1), with the consequent inhibitions of both fibroblast proliferation and collagen production.

Topical use appears to match oral therapy for antiproliferative activity in ductal carcinoma in situ (DCIS).  Transdermal delivery of tamoxifen offers a potential means to use the breast’s well-developed natural lymphatic system to achieve high local concentrations with minimal systemic exposure.

http://www.ncbi.nlm.nih.gov/pubmed/19636578

http://www.medpagetoday.com/HematologyOncology/BreastCancer/46783

 

 

 

By | 2014-08-07T08:56:06+00:00 August 7th, 2014|Morag's desk|Comments Off on Tamoxifen – breast cancer and scar use?