>, Morag's desk>5-FU for Keloid Scar Reduction

5-FU for Keloid Scar Reduction

This multi-purpose drug known as Flourouracil (5-fluorouracil or 5-FU) aka Adrucil® is popping up again….we know this drug is commonly used as a chemotherapy drug for various cancers such as breast CA, colorectal CA, head and neck cancers and others, plus skin cancer known as superficial basal cell carcinoma.  We do know that this drug affects the melanocytes in the skin and it can induce changes to skin color.  We also know this drug can cause excessive itching and therefore causing color changes called flagellate pigmentation

As a topical drug Fluorouracil cream and topical solution are used to treat actinic or solar keratoses (scaly or crusted lesions on the skin in areas exposed to years of UV radiation).

Now a new invention provides a simple, affordable and — most importantly — highly effective way for patients to self-treat keloid scars.  Keloid scars that result from an overgrowth of skin tissue after injuries or surgeries are unsightly and can even lead to disfigurement and psychological problems. Individuals with darker skins such as African, Hispanic or South-Asian genetic background are more susceptible to keloid scars.  Available therapy options include surgery and/or cortisone injections into the scar tissue but these are often ineffective.

A patch is made from polymers fabricated into microneedles, of which the microneedles are loaded with 5-fluorouracil. The microneedles attach the patch to an area of scar tissue and the drug and needs together contribute to the efficacy of the patch which leads to the cessation of scar tissue growth and a considerable reduction of keloids.  Results have been noted in laboratory cultures and experiments with animals.

Since many people are looking for treatment for scars that cause disfigurement and/or pain or itching, this patch can be self-administered!

More information on the patch: https://www.sciencedaily.com/releases/2014/06/140623120400.htm

By | 2017-07-17T05:44:25+00:00 July 17th, 2017|Articles and News, Morag's desk|Comments Off on 5-FU for Keloid Scar Reduction

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